Sarah Cale's work as a painter has entailed a search for strategies that complicate and disrupt historically accepted painterly gestures. Her work occupies a performative position, creating works where meaning comes from the raw materiality of a painting itself, rather than conventional language used to describe it. She combines a textile-based practice to widen a critical stance towards painting and to access a range of material potentials that stem from craft traditions and traditional textile production.

Recent works occupy an eco-feminist stance using natural fibres to create handwoven 'drawings' and knot-tied jute tapestries which are applied as the material starting point for painted narratives and large-scale textile works. She used traditional weaving and creates textile-cast ceramics to further narratives surrounding 'human-made' labour, creating works that intrinsically self-reflect on the methods in which they are made.